He is the head staff manager of research on the diclonius children in Chief Kakuzawa's island facility and also Kurama's subordinate in his mid-40's. He's portrayed as an uncaring, callous, and analytical figure towards the Diclonius just like the rest of the scientists experimenting on them. Both his role and physical appearance are slightly altered for the manga, he is seen few times paired up with Bando but it does not seem to affect the general plot in any way.

Isobe views all Diclonius as dangerous threats to humankind's existence that need to be permanently caged or "put to sleep" like animals. In the final episode he is decapitated by Lucy, when he tries to take advantage of the situation and shoot Nana.

In the manga he is killed by Mariko after she tricks him into giving her the code to stop the bombs within her from blowing up.



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